Colonoscopy with Biopsy: what it covers and what it costs
What does a Colonoscopy with Biopsy cost? Across 35 major U.S. metros, the typical insurer-negotiated price for a Colonoscopy w/ Biopsy (CPT 45380) runs from about $330 in Indianapolis, IN to $8,385 in Jacksonville, FL, read from hospitals' own price-transparency files. 11 of those metros have at least one hospital publishing a self-pay cash price. This page explains what the billing code covers, what the quoted price does and does not include, and what actually drives the spread between hospitals. These are price references from public data — not a quote, a bill, or medical or financial advice.
These figures are aggregated from hospitals' public price-transparency files — not a quote, a bill, an insurance benefit determination, or medical advice. Your actual out-of-pocket cost depends on your insurance plan (deductible, copay, coinsurance, network), the exact service and any complications, and which hospital you use. Always confirm price and coverage with the hospital and your insurer before care.
What a Colonoscopy w/ Biopsy price actually covers
A colonoscopy with biopsy is the same examination as a diagnostic colonoscopy, with tissue sampled for laboratory analysis. Taking a biopsy moves the procedure to its own code, above the base examination.
Code scope. 45380 = colonoscopy with biopsy (cold forceps). Polyp removal by snare is 45385; by hot biopsy/ablation is 45384/45388.
What is — and isn't — in the price
The facility and physician charges cover the procedure itself. The pathology examination of the sampled tissue is billed separately by a laboratory or pathology group and does not appear in a hospital's published procedure price at all.
Why Colonoscopy w/ Biopsy prices differ so much between hospitals
Beyond the usual hospital-versus-endoscopy-centre spread, the number and method of tissue removal matters: biopsy, snare polypectomy and removal by other techniques are distinct codes. A procedure that begins as a screening examination and takes a polyp is billed under this class instead.
What else usually lands on the bill
Pathology is the charge patients least expect and is billed per specimen container, so multiple polyps can mean multiple pathology lines. Snare polypectomy, hot biopsy and endoscopic mucosal resection are separate codes.
What to ask before you book
Ask whether the quote includes pathology — it usually does not — and what the charge becomes if more than one polyp is removed by more than one technique.
Where the money actually moves
Site of service dominates, as with any endoscopy. Ask in advance which pathology laboratory the practice uses and whether it participates with your plan; that bill arrives weeks later from an entity you never chose.
What the Colonoscopy w/ Biopsy numbers show nationally
A Colonoscopy w/ Biopsy costs 25.4× as much in Jacksonville as in Indianapolis
Across the 35 metros priced here, the typical negotiated rate runs from $330 in Indianapolis, IN to $8,385 in Jacksonville, FL — the same billing codes, the same procedure, 2440% apart.
The individual hospitals reporting the lowest and highest Colonoscopy w/ Biopsy prices
Lowest: SHARP CHULA VISTA MEDICAL CENTER (San Diego, CA) at $1; HARPER UNIVERSITY HOSPITAL (Detroit, MI) at $10; FRANCISCAN HEALTH INDIANAPOLIS (Indianapolis, IN) at $153. Highest: CEDARS-SINAI MEDICAL CENTER (Los Angeles, CA) at $18,056; NICKLAUS CHILDREN'S HOSPITAL (Miami, FL) at $8,966; ASCENSION ST VINCENT'S SOUTHSIDE (Jacksonville, FL) at $8,427. These are the figures each hospital published in its own file, not an assessment of the care.
11 of 35 metros have a hospital publishing a self-pay Colonoscopy w/ Biopsy price
Cheapest published cash price: $951 (Detroit). A cash price is what the hospital will accept from someone paying directly; it is not required and many never publish one.
Insurers pay about 63% below the list price for a Colonoscopy w/ Biopsy
Across the 12 metros publishing both, the chargemaster list price is typically 63% above what insurers negotiate. The widest gap is in Cincinnati: $12,218 list against $1,166 negotiated.
How many hospitals actually publish a Colonoscopy w/ Biopsy price
222 hospital price-file entries across 35 metros feed this page. A hospital appears only where its own file lists a rate for CPT 45380 — where it does not, it is absent from the table rather than filled in with a guess.
Colonoscopy w/ Biopsy price by metro
The typical insurer-negotiated price for a Colonoscopy w/ Biopsy, by metro — lowest first. 11 of these 35 metros have at least one hospital publishing a self-pay cash price; 12 publish a chargemaster list price. Open a metro for its full hospital-by-hospital breakdown and who those hospitals are.
| Metro | Typical negotiated | Range | Cash | Hospitals |
|---|---|---|---|---|
| Indianapolis, IN | $330 | $153–$330 | — | 3 |
| Raleigh, NC | $747 | $747–$755 | — | 3 |
| Detroit, MI | $1,161 | $10–$1,243 | $951 | 6 |
| Cincinnati, OH | $1,166 | $1,166–$1,186 | $7,331 | 5 |
| Phoenix, AZ | $1,267 | $1,267–$2,897 | — | 10 |
| St. Louis, MO | $1,296 | $1,089–$1,850 | $3,409 | 7 |
| Tampa, FL | $1,325 | $1,312–$1,361 | — | 6 |
| San Diego, CA | $1,394 | $1–$4,563 | $2,756 | 6 |
| Riverside, CA | $1,433 | $330–$3,145 | — | 4 |
| Buffalo, NY | $1,486 | $277–$2,017 | — | 3 |
| Sacramento, CA | $1,497 | $702–$1,497 | $3,550 | 4 |
| San Francisco, CA | $1,497 | $1,497 | $3,550 | 6 |
| Hartford, CT | $1,528 | $1,410–$3,371 | — | 4 |
| Milwaukee, WI | $1,698 | $1,168–$3,119 | — | 9 |
| Birmingham, AL | $1,847 | $932–$3,163 | — | 8 |
| Kansas City, MO | $1,863 | $1,193–$3,092 | — | 7 |
| Nashville, TN | $2,178 | $1,535–$2,459 | — | 9 |
| Pittsburgh, PA | $2,223 | $352–$3,245 | $4,331 | 5 |
| New York, NY | $2,255 | $2,008–$4,805 | $3,675 | 7 |
| Philadelphia, PA | $2,343 | $1,301–$6,648 | $4,910 | 13 |
| Houston, TX | $2,402 | $2,299–$2,444 | — | 6 |
| Washington, DC | $2,431 | $2,431–$3,649 | — | 5 |
| Seattle, WA | $2,487 | $1,204–$3,143 | — | 7 |
| Austin, TX | $3,160 | $723–$3,734 | — | 9 |
| Atlanta, GA | $3,295 | $416–$4,714 | $1,392 | 9 |
| San Jose, CA | $3,367 | $1,497–$4,851 | — | 3 |
| Los Angeles, CA | $3,380 | $1,433–$18,056 | — | 5 |
| Miami, FL | $3,650 | $2,210–$8,966 | — | 4 |
| Cleveland, OH | $3,667 | $188–$4,713 | $3,526 | 9 |
| Chicago, IL | $3,982 | $3,982 | — | 3 |
| Portland, OR | $4,128 | $1,430–$4,128 | — | 7 |
| Denver, CO | $4,139 | $190–$4,699 | — | 10 |
| Dallas, TX | $4,533 | $2,243–$5,898 | — | 10 |
| Virginia Beach, VA | $5,790 | $4,564–$5,790 | — | 6 |
| Jacksonville, FL | $8,385 | $5,727–$8,427 | — | 3 |
Source: hospitals' own machine-readable Standard Charges files, published under the U.S. Hospital Price Transparency rule (45 CFR §180.50). Most recent hospital file in this dataset: July 2026. Prices are references, not quotes or bills, and never medical or financial advice — where a hospital reports no price, nothing is shown rather than a guess.
Frequently asked questions
- How much does a Colonoscopy w/ Biopsy cost?
- Across 35 U.S. metros the typical insurer-negotiated price is about $2,223, ranging from $330 in Indianapolis to $8,385 in Jacksonville. Every figure is read from a named hospital's own price-transparency file for CPT 45380.
- Does the price include the doctor's fee?
- The facility and physician charges cover the procedure itself. The pathology examination of the sampled tissue is billed separately by a laboratory or pathology group and does not appear in a hospital's published procedure price at all.
- Why do Colonoscopy w/ Biopsy prices differ so much between hospitals?
- Beyond the usual hospital-versus-endoscopy-centre spread, the number and method of tissue removal matters: biopsy, snare polypectomy and removal by other techniques are distinct codes. A procedure that begins as a screening examination and takes a polyp is billed under this class instead.